Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
"You can no longer have some countries go first and others come in later, because there is no more time," said Glen P. Peters, a scientist at the Center for International Climate and Environmental Research in Oslo, who helped compile the new numbers. "It needs to be all hands on deck now."
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Blake Griffin's high school appearance isn't that far off from how he looks today. Just add some hair and some size to his biceps, and you've got Blake Griffin today.
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Chinese exports rose at more than twice the rate expected in November, boosting the country’s trade surplus.
The Brexit trade uncertainty
Trends and targets in antiviral phototherapy
But closing the deal on RCEP less than a year after Donald Trump pulled the US out of the TPP would be a big win for Beijing.
The joint programme delivered by IQS of Spain, Fu Jen Catholic University in Taiwan and the University of San Francisco saw the biggest rise. Its Master in Global Entrepreneurship Management jumps 34 places to 43rd, making up for a drop of 19 places the previous year. The only programme to be delivered on three continents, it is ranked top for international course experience.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Novel biosensing methodologies for ultrasensitive detection of viruses
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
ACE2 as a potential therapeutic target for pandemic COVID-19
4. Adidas. Brand love: 35% / Rank 25
Meanwhile, he was being ferried around the globe to tech conferences, getting introduced to other potential investors. D'Aloisio made a remarkable impression on everyone he crossed paths with. 'He has an eerie maturity,' says Andrew Halls, headmaster of the King's College School in Wimbledon, which D'Aloisio has attended since he was 11. 'He has an extraordinary articulateness in the face of situations that, for me, even as a 54-year-old, might be terrifying.'
Diagnostic technologies for COVID-19: a review
《内布拉斯加》(Nebraska)以明快的黑白片形式拍摄，通过一次穿越蒙大拿和内布拉斯加的旅行揭示了由布鲁斯?邓恩(Bruce Dern)扮演的易怒老头伍迪?格兰特(Woody Grant)的内心世界。（这部电影的摄影师芬顿?帕帕迈可(Phedon Papamichael)也参演了影片。）编剧鲍勃?尼尔森(Bob Nelson)炮制了优秀的剧本，而亚历山大?佩恩(Alexander Payne)的导演工作也无懈可击。这部影片讲述的是伍迪和儿子威尔(Will)关系不佳、最终和解的过程；扮演儿子的威尔?福特(Will Forte)极度平和的表演征服了观众。这里是很少在银幕上得到刻画的美国心脏地带，带着幽默和几乎可以感知的深情。
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Yes. Mr Modi’s overnight ban on using high-value bank notes was a big shock, and seriously disrupted the economy. But it delivered rich political rewards, bolstering the premier’s image as a decisive leader willing to take tough action against corruption. With the next general elections due in 2019, Mr Modi will be tempted to deliver one more big bang to dazzle voters. Watch out for dramatic action against wealthy individuals holding properties in others’ names to hide their ownership.
Recipient: Their Royal Highnesses The Duke and Duchess of Cambridge (joint winners)
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Online peer-to-peer lending platforms have expanded rapidly in China, along with fraud cases.
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
An industry insider said the survey indicated that China was in the process of an industrial upgrade and a high value-added service sector was on the rise. This is leading to a thriving Internet industry, which needs science and engineering professionals, and a booming finance industry, which requires finance and economics professionals.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
6. Gene therapy comes good.
Antiviral drug discovery: broad-spectrum drugs from nature
The S&P 500’s total return of 14% this year was 40% higher than its 25-year average annual gain. Wall Street’s chief strategists spent much of the last 12 months revising their targets higher from behind. The index printed over 50 all-time record closes, with nearly all investment management professionals racing to at least pull even. A few characteristics made the U.S. stock market particularly difficult to keep up with this year.
Influenza neuraminidase: A druggable target for natural products
Of course, these same new forces may also trigger a backlash and a reversion to old command-and-control ways of leading. The politicians who dominate the world stage are, depressingly, mostly cut from the old cloth, and the leadership challenges they face, from Brexit to North Korea, are particularly complex.
Talking to Town & Country, Industry Kitchen Executive Chef Braulio Bunay said he was inspired to create the pizza by the city's Financial District, which he described as 'the epitome of decadence'.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
May the glow of New Year candle fill your heart with peace and pleasure and make your New Year bright.
The role of biosensors in the detection of emerging infectious diseases
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
The fruit is placed into the mold when it's young and undeveloped.
5、Poor e-mail communication
The North has already warned that Park will "pay for his crimes in blood" if copies of the film make it across the border.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Will Emmanuel Macron secure a commitment from German chancellor Angela Merkel on a eurozone budget
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Inhibition of SARS coronavirus helicase by bismuth complexes
China's Internet industry is often derided as a realm for knockoffs, especially of companies banned in China. Chinese search giant Baidu Inc. has a website that looks like Google Inc's. Tencent's flagship product, instant messaging service QQ, was launched in 1999 as OICQ and had similar functions to then-popular instant messaging service ICQ. Sina Corp.'s Weibo, a popular microblogging service, is invariably described as 'Twitter-like' in the Western media.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
这是传记类作品首次赢得该奖项，尽管格林斯潘的自传《动荡年代》(The Age of Turbulence)曾在2007年入围终选名单——一年之后爆发的金融危机，引发了对这位中央银行家遗产的强烈质疑。
Tumor Biology, a journal published by Springer Nature, announced last week that it had retracted the papers after an investigation showed the peer review process had been compromised.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
7. How to get a flat stomach
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
However, the economists polled expect slightly higher growth rates and substantially higher inflation over 2016.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
6) My Pleasure: This subtle reminder reinforces a key point. You’re here to help others. You have all the time they need. And you’re happy to do it.
"Game of Thrones" was not only the most downloaded show of the TV season, but also the most downloaded show of the year. In fact, the per episode illegal downloads figure is higher than the best ratings "Game of Thrones" has ever had。
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
The Martian was named best comedy or musical motion picture.
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
The data highlight the growing anxieties in some sectors of industry about what they see as unfair competition from Chinese rivals.
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
1977：“俄罗斯型流感”H1N1感染人类1977: "Russian flu" H1N1 Infects Humans
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Google's brand is now worth more than 109 billion U.S. dollars, around 2 billion dollars more than Apple, making it the most lucrative in the world.
Local educational authorities have since revoked Zhengzhou Boqiang New Idea Life Training School's license and launched an investigation into its record. Hauntingly, the school's website remains online, replete with photos of students in camouflage uniforms performing drills and attending what the site labels "wonderful lectures."
Maybe 'Melo's mini-fro is the missing key to an NBA Championship for the New York Knicks. Oh no, wait, the missing link is Jeremy Lin—but still, 'Melo's mini-fro wouldn't hurt the Knicks' title hopes.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Among 36,000 who have reached celebrity status on the Internet, 74 percent are women and 87.8 percent are between 17 to 33 years old, while 89 percent have a college education. Followers are also getting younger and better educated, with 77.8 percent in the 17-to-33 age group and 75 percent with a higher education.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
But Huy Vo, a senior specialist in public relations at Hawaiian, said the short flights, which make up half the airline’s routes, aren’t all that easy to operate. “Our geographic location certainly does give us an advantage, as well as our short-haul routes, ” Vo said. “However, the short-haul routes are the hardest to keep punctual, because the hops are very short, with brief ground time between flights, so any delay is difficult to make up.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
在开放课程排行榜顶端，赛德商学院(Sa?d Business School)排名上升幅度最大，跃升5位至第4名。这是这所位于牛津大学(University of Oxford)的商学院首次进入前五。赛德商学院在所有10项受学员评分影响的指标上的排名都有所提升。
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Season\'s greetings and sincere wishes for a bright and happy New Year!
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Liu Fei was also a half-brother of the Emperor Wu of Han who ruled from 141BC to 97BC.
However, in season two Friends took a big leap toward equality by featuring a gay wedding when Carol married her girlfriend Susan. Behind the scenes, executive producer Marta Kauffman said, "NBC expected thousands and thousands of phone calls and hate mail." However, after the episode aired, they received only four antagonistic letters. As it turns out, people just didn't care that much.
A modular microarray imaging system for highly specific COVID-19 antibody testing
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
His eloquent defence of equality came after a year of faltering progress on gay marriage in the US and as arguments rage about the lack of diversity among the people running the Silicon Valley companies, including Apple, who shape so much of our culture.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
挪威曾为一只企鹅授予爵位。它现在居住在苏格兰的爱丁堡动物园，是那里的企鹅王，它叫尼尔斯·奥拉夫（ Nils Olav）。它不仅是一只吉祥物，更是挪威皇家护卫队的名誉上校。2008年8月15日，国王哈拉尔五世（King Harald V）授予奥拉夫爵位，并在授予典礼上声明“奥拉夫在各方面都有资格获得骑士爵位的荣誉和尊严”。
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
A Larger Profile
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
He said game and live-broadcast apps currently hosted by Tencent don't require real-name registration, but the company is considering establishing a platform for parents to monitor their children's behavior.
The Suicide Squad is scheduled for an August 5th 2016 release.
A facile assay for rapid detection of COVID-19 antibodies
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Tony Moloney, head of education and skills at National Grid, says the UK utility’s involvement is part of its broader strategy to encourage school students to study Stem subjects — science, technology, engineering and mathematics — and learn more about jobs in his sector.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
It was in Giambattista Valli’s most recent autumn-winter show, full of puffed-sleeve printed tunics over matching trousers and drop-waisted schoolgirls shifts, and in MaxMara’s ode to Marilyn Monroe’s 1962 photo shoot with George Barris.
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Jack Ma, founder and executive chairman of e-commerce giant Alibaba Group topped the ranking of China's richest IT people for the third consecutive year.
Growth in the key sectors driving China’s economy softened last month, according to official gauges tracking activity at manufacturing, services and construction businesses.
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Any decision by China’s policymakers to begin selling down the country’s huge reserves would have a large impact on markets.
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
The captain must steer the ship. If leadership doesn’t know where a project or company is headed, how can the company know? This isn’t just about steps or deliverables, either, but a clear vision of the department or company’s future that he or she can communicate to the employees。
Anti-HIV drug repurposing against SARS-CoV-2
在导演阿方索?卡隆(Alfonso Cuaron)和同事们（其中包括知名电影摄影师艾曼努尔?卢贝兹基(Emmanuel Lubezki)、制片设计师安迪?尼克尔森(Andy Nicholson)和编剧霍纳斯?卡隆(Jonas Cuaron)）的共同努力下，《地心引力》丰富了电影的拍摄手法。《美国电影摄影师》(American Cinematographer)杂志上个月的封面故事刊载了关于《地心引力》制作过程的文章，对电影技术感兴趣的读者可以一探究竟。读者们可以在网上阅读该杂志。不过任何看过《地心引力》的观众都已经领会到了该片的情感内涵，这部电影把观众们带进入了一个寂静危险的外太空和一个深度愉悦的内心世界。
The University of St Gallen’s domination of the Financial Times’ ranking of masters in management courses continues for another year.
Length-scale dependence of protein hydration-shell density
I don't know about you, but if I had a separate calendar for work, school and life, I'd be a complete mess. When everything in your life is on one calendar, in one planner, you can't double-book anything. You know, like an important test and a dinner with your boss.
6. “Taxi”(Jafar Panahi)
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
With an 8.5-percent increase in profits, industrial enterprises reversed the previous year's negative growth of 2.3 percent.
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
JUSTIFIED (FX, Jan. 20) The series-long love-hate relationship between Deputy Marshal Raylan Givens (Timothy Olyphant) and his friend and nemesis Boyd Crowder (Walton Goggins) will be resolved, one way or another, in the show’s sixth and final season.
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“Someone resigned via a video conference call.”
The infectious disease known as scarlet fever famously reached pandemic proportions in the 19th century, striking down the young and the weak across the Western world.